mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity

Khalid W. Kalim; Shuangmin Zhang; Xiaoyi Chen; Yuan Li; Jun-Qi Yang; Yi Zheng; Fukun Guo

doi:10.1371/journal.pone.0183266

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Open Access

Peer-reviewed

Research Article

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity

Khalid W. Kalim,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America
⨯
Shuangmin Zhang,

Roles Data curation, Formal analysis, Methodology

Affiliation Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America
⨯
Xiaoyi Chen,

Roles Data curation, Formal analysis, Methodology

Affiliation Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America
⨯
Yuan Li,

Roles Data curation

Affiliation Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America
⨯
Jun-Qi Yang,

Roles Data curation

Affiliations Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America, Key Laboratory for Parasitic Disease Control and Prevention, Ministry of Health, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu, China
⨯
Yi Zheng ,

Roles Conceptualization, Formal analysis, Resources

* E-mail: fukun.guo@cchmc.org (FG); yi.zheng@cchmc.org (YZ)

Affiliation Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America
⨯
Fukun Guo

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: fukun.guo@cchmc.org (FG); yi.zheng@cchmc.org (YZ)

Affiliation Division of Experimental Hematology and Cancer Biology, Children’s Hospital Research Foundation, Cincinnati, Ohio, United States of America

http://orcid.org/0000-0002-8820-7633

⨯

mTOR has a developmental stage-specific role in mitochondrial fitness independent of conventional mTORC1 and mTORC2 and the kinase activity

Khalid W. Kalim,
Shuangmin Zhang,
Xiaoyi Chen,
Yuan Li,
Jun-Qi Yang,
Yi Zheng,
Fukun Guo

Published: August 16, 2017
https://doi.org/10.1371/journal.pone.0183266

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