Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria

Divakara S. S. M. Uppu; Mohini M. Konai; Paramita Sarkar; Sandip Samaddar; Isabel C. M. Fensterseifer; Celio Farias-Junior; Paramanandam Krishnamoorthy; Bibek R. Shome; Octávio L. Franco; Jayanta Haldar

doi:10.1371/journal.pone.0183263

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Open Access

Peer-reviewed

Research Article

Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria

Divakara S. S. M. Uppu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Current address: Infectious Diseases Interdisciplinary Research Group (ID-IRG), Singapore-MIT Alliance for Research and Technology (SMART), Singapore

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka, India
⨯
Mohini M. Konai,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka, India
⨯
Paramita Sarkar,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka, India
⨯
Sandip Samaddar,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka, India
⨯
Isabel C. M. Fensterseifer,

Roles Data curation, Formal analysis, Methodology, Validation

Affiliations Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia UC, Brası´lia, Brazil, Molecular Pathology Post-Graduate Program, University of Brasília, Brasília, Brazil
⨯
Celio Farias-Junior,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Lacen, Laboratorio Central, Brasília, DF, Brazil
⨯
Paramanandam Krishnamoorthy,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India
⨯
Bibek R. Shome,

Roles Funding acquisition, Investigation, Methodology, Resources

Affiliation ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Bengaluru, Karnataka, India
⨯
Octávio L. Franco,

Roles Funding acquisition, Investigation, Resources

Affiliations Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia UC, Brası´lia, Brazil, Molecular Pathology Post-Graduate Program, University of Brasília, Brasília, Brazil, S-inova Biotech, Pos-Graduação em Biotecnoloia, Universidade Catolica Dom Bosco, Campo Grande, Brazil
⨯
Jayanta Haldar

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: jayanta@jncasr.ac.in

Affiliation Chemical Biology & Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, Karnataka, India

http://orcid.org/0000-0002-8068-1015

⨯

Membrane-active macromolecules kill antibiotic-tolerant bacteria and potentiate antibiotics towards Gram-negative bacteria

Divakara S. S. M. Uppu,
Mohini M. Konai,
Paramita Sarkar,
Sandip Samaddar,
Isabel C. M. Fensterseifer,
Celio Farias-Junior,
Paramanandam Krishnamoorthy,
Bibek R. Shome,
Octávio L. Franco,
Jayanta Haldar

Published: August 24, 2017
https://doi.org/10.1371/journal.pone.0183263

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Antibiotics
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Bacterial biofilms
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Erythromycin
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Macromolecules
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Cell membranes
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