HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma

Donald Ewert; Ning Hu; Xiaoping Du; Wei Li; Matthew B. West; Chul-Hee Choi; Robert Floyd; Richard D. Kopke

doi:10.1371/journal.pone.0183089

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Peer-reviewed

Research Article

HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma

Donald Ewert,

Roles Data curation, Formal analysis, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Hough Ear Institute, Oklahoma City, OK, United States of America

http://orcid.org/0000-0001-5495-7156

⨯
Ning Hu,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Department of Biology, University of Iowa, Iowa City, IA, United States of America
⨯
Xiaoping Du,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Hough Ear Institute, Oklahoma City, OK, United States of America
⨯
Wei Li,

Roles Investigation, Visualization

Affiliation Hough Ear Institute, Oklahoma City, OK, United States of America
⨯
Matthew B. West,

Roles Writing – review & editing

Affiliation Hough Ear Institute, Oklahoma City, OK, United States of America
⨯
Chul-Hee Choi,

Roles Conceptualization, Methodology

Affiliation Audiology & Speech-Language Pathology & Research Institute of Biomimetic Sensory Control, College of Medical Sciences, Catholic University of Daegu, Gyeongsangbuk-do, South Korea
⨯
Robert Floyd,

Roles Writing – review & editing

Affiliation Oklahoma Medical Research Foundation, Oklahoma City, OK, United States of America
⨯
Richard D. Kopke

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – review & editing

* E-mail: rkopke@houghear.org

Affiliations Hough Ear Institute, Oklahoma City, OK, United States of America, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States of America, Departments of Physiology and Otolaryngology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States of America
⨯

HPN-07, a free radical spin trapping agent, protects against functional, cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma

Donald Ewert,
Ning Hu,
Xiaoping Du,
Wei Li,
Matthew B. West,
Chul-Hee Choi,
Robert Floyd,
Richard D. Kopke

Published: August 23, 2017
https://doi.org/10.1371/journal.pone.0183089

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