Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro

Sevasti Zervou; Hannah J. Whittington; Philip J. Ostrowski; Fang Cao; Jack Tyler; Hannah A. Lake; Stefan Neubauer; Craig A. Lygate

doi:10.1371/journal.pone.0182994

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Peer-reviewed

Research Article

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro

Sevasti Zervou ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: szervou@well.ox.ac.uk

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom

http://orcid.org/0000-0002-4665-2747

⨯
Hannah J. Whittington,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom
⨯
Philip J. Ostrowski,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom
⨯
Fang Cao,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom
⨯
Jack Tyler,

Roles Conceptualization, Data curation, Formal analysis, Software, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom
⨯
Hannah A. Lake,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom
⨯
Stefan Neubauer,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom
⨯
Craig A. Lygate

Roles Conceptualization, Funding acquisition, Investigation, Project administration, Writing – original draft, Writing – review & editing

Affiliation Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford,Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, United Kingdom
⨯

Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro

Sevasti Zervou,
Hannah J. Whittington,
Philip J. Ostrowski,
Fang Cao,
Jack Tyler,
Hannah A. Lake,
Stefan Neubauer,
Craig A. Lygate

Published: August 14, 2017
https://doi.org/10.1371/journal.pone.0182994

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Creatine
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Cell death
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Mitochondria
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Transfection
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Hypoxia
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Heart
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