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Open Access

Peer-reviewed

Research Article

Highly efficient gene inactivation by adenoviral CRISPR/Cas9 in human primary cells

Olaf Voets,

Roles Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Galapagos BV, CL Leiden, The Netherlands

http://orcid.org/0000-0002-7827-9211

⨯
Frans Tielen,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯
Edo Elstak,

Roles Investigation, Software, Visualization

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯
Julian Benschop,

Roles Resources

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯
Max Grimbergen,

Roles Resources

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯
Jan Stallen,

Roles Conceptualization, Project administration

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯
Richard Janssen ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: richard.janssen@glpg.com

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯
Andre van Marle,

Roles Conceptualization, Supervision

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯
Christian Essrich

Roles Conceptualization, Project administration, Supervision, Writing – review & editing

Affiliation Galapagos BV, CL Leiden, The Netherlands
⨯

Highly efficient gene inactivation by adenoviral CRISPR/Cas9 in human primary cells

Olaf Voets,
Frans Tielen,
Edo Elstak,
Julian Benschop,
Max Grimbergen,
Jan Stallen,
Richard Janssen,
Andre van Marle,
Christian Essrich

x

Published: August 11, 2017
https://doi.org/10.1371/journal.pone.0182974

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Guide RNA
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CRISPR
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Genomics
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Primary cells
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Drug discovery
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Polymerase chain reaction
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Human genomics
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RNA interference
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