Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses

Trillitye Paullin; Chase Powell; Christopher Menzie; Robert Hill; Feng Cheng; Christopher J. Martyniuk; Sandy D. Westerheide

doi:10.1371/journal.pone.0182930

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Peer-reviewed

Research Article

Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses

Trillitye Paullin,

Affiliation Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, United States of America
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Chase Powell,

Affiliation Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, United States of America
⨯
Christopher Menzie,

Affiliation Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, United States of America
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Robert Hill,

Affiliation Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, United States of America
⨯
Feng Cheng,

Affiliations Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, Florida, United States of America, Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, Florida, United States of America
⨯
Christopher J. Martyniuk ,

* E-mail: cmartyn@ufl.edu (CJM); swesterheide@usf.edu (SDW)

Affiliation Center for Environmental and Human Toxicology & Department of Physiological Sciences, UF Genetics Institute, University of Florida, Gainesville, Florida, United States of America
⨯
Sandy D. Westerheide

* E-mail: cmartyn@ufl.edu (CJM); swesterheide@usf.edu (SDW)

Affiliation Department of Cell Biology, Microbiology, and Molecular Biology, College of Arts and Sciences, University of South Florida, Tampa, Florida, United States of America

http://orcid.org/0000-0003-4683-9648

⨯

Spheroid growth in ovarian cancer alters transcriptome responses for stress pathways and epigenetic responses

Trillitye Paullin,
Chase Powell,
Christopher Menzie,
Robert Hill,
Feng Cheng,
Christopher J. Martyniuk,
Sandy D. Westerheide

Published: August 9, 2017
https://doi.org/10.1371/journal.pone.0182930

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Ovarian cancer
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Gene expression
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DNA-binding proteins
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Transcription factors
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Cancers and neoplasms
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DNA damage
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Heat shock response
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Cancer treatment
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