B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis

Rita A. Moura; Cláudia Quaresma; Ana R. Vieira; Maria J. Gonçalves; Joaquim Polido-Pereira; Vasco C. Romão; Nádia Martins; Helena Canhão; João E. Fonseca

doi:10.1371/journal.pone.0182927

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Open Access

Peer-reviewed

Research Article

B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis

Rita A. Moura ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ritaaguiarmoura@gmail.com

Affiliation Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal

http://orcid.org/0000-0002-9685-6924

⨯
Cláudia Quaresma ,

Contributed equally to this work with: Cláudia Quaresma, Ana R. Vieira

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – review & editing

Affiliation Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
⨯
Ana R. Vieira ,

Contributed equally to this work with: Cláudia Quaresma, Ana R. Vieira

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing

Affiliation Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
⨯
Maria J. Gonçalves,

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliations Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon Academic Medical Centre, Lisbon, Portugal
⨯
Joaquim Polido-Pereira,

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliations Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon Academic Medical Centre, Lisbon, Portugal
⨯
Vasco C. Romão,

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliations Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon Academic Medical Centre, Lisbon, Portugal
⨯
Nádia Martins,

Roles Data curation, Investigation, Resources, Writing – review & editing

Affiliation Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon Academic Medical Centre, Lisbon, Portugal
⨯
Helena Canhão,

Roles Data curation, Formal analysis, Investigation, Resources, Writing – review & editing

Affiliations Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon Academic Medical Centre, Lisbon, Portugal
⨯
João E. Fonseca

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon Academic Medical Centre, Lisbon, Portugal
⨯

B-cell phenotype and IgD-CD27- memory B cells are affected by TNF-inhibitors and tocilizumab treatment in rheumatoid arthritis

Rita A. Moura,
Cláudia Quaresma,
Ana R. Vieira,
Maria J. Gonçalves,
Joaquim Polido-Pereira,
Vasco C. Romão,
Nádia Martins,
Helena Canhão,
João E. Fonseca

Published: September 8, 2017
https://doi.org/10.1371/journal.pone.0182927

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B cells
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Gene expression
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