Hyperphosphorylation of RPS6KB1, rather than overexpression, predicts worse prognosis in non-small cell lung cancer patients

Bojiang Chen; Lan Yang; Rui Zhang; Yuncui Gan; Wen Zhang; Dan Liu; Hong Chen; Huairong Tang

doi:10.1371/journal.pone.0182891

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Open Access

Peer-reviewed

Research Article

Hyperphosphorylation of RPS6KB1, rather than overexpression, predicts worse prognosis in non-small cell lung cancer patients

Bojiang Chen,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Software, Writing – original draft, Writing – review & editing

Affiliation Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
⨯
Lan Yang,

Roles Investigation, Software, Writing – original draft

Affiliation Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
⨯
Rui Zhang,

Roles Data curation, Formal analysis, Software, Writing – original draft

Affiliation Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
⨯
Yuncui Gan,

Roles Data curation, Formal analysis, Validation, Visualization

Affiliation Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
⨯
Wen Zhang,

Roles Investigation, Methodology, Software

Affiliation Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
⨯
Dan Liu,

Roles Software, Supervision, Validation, Visualization

Affiliation Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China
⨯
Hong Chen ,

Roles Conceptualization, Data curation, Writing – review & editing

* E-mail: 1651682099@qq.com (HRT); yisabei@sina.com (HC)

Affiliation Department of General Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, China
⨯
Huairong Tang

Roles Conceptualization, Writing – review & editing

* E-mail: 1651682099@qq.com (HRT); yisabei@sina.com (HC)

Affiliation Health Management Center, West China Hospital, Sichuan University Chengdu, Sichuan, China
⨯

Hyperphosphorylation of RPS6KB1, rather than overexpression, predicts worse prognosis in non-small cell lung cancer patients

Bojiang Chen,
Lan Yang,
Rui Zhang,
Yuncui Gan,
Wen Zhang,
Dan Liu,
Hong Chen,
Huairong Tang

Published: August 9, 2017
https://doi.org/10.1371/journal.pone.0182891

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Non-small cell lung cancer
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Apoptosis
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Phosphorylation
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Squamous cell carcinoma
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Adenocarcinoma
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Cell cycle and cell division
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Immunohistochemistry techniques
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