Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease

Hansen Wang; Declan Williams; Jennifer Griffin; Takashi Saito; Takaomi C. Saido; Paul E. Fraser; Ekaterina Rogaeva; Gerold Schmitt-Ulms

doi:10.1371/journal.pone.0182844

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Peer-reviewed

Research Article

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APP^NL-F mouse model of Alzheimer disease

Hansen Wang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada
⨯
Declan Williams,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada
⨯
Jennifer Griffin,

Roles Resources

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada
⨯
Takashi Saito,

Roles Resources

Affiliation Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Hirosawa, Wako-shi, Saitama, Japan
⨯
Takaomi C. Saido,

Roles Resources

Affiliation Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Hirosawa, Wako-shi, Saitama, Japan
⨯
Paul E. Fraser,

Roles Resources

Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada, Department of Medical Biophysics, University of Toronto, Toronto, Canada
⨯
Ekaterina Rogaeva,

Roles Methodology, Resources, Writing – review & editing

Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada, Department of Medicine (Neurology), University of Toronto, Toronto, Canada
⨯
Gerold Schmitt-Ulms

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – review & editing

* E-mail: g.schmittulms@utoronto.ca

Affiliations Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Canada

http://orcid.org/0000-0001-6962-0919

⨯

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APP^NL-F mouse model of Alzheimer disease

Hansen Wang,
Declan Williams,
Jennifer Griffin,
Takashi Saito,
Takaomi C. Saido,
Paul E. Fraser,
Ekaterina Rogaeva,
Gerold Schmitt-Ulms

Published: August 23, 2017
https://doi.org/10.1371/journal.pone.0182844

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