Plasma metabolomics reveals membrane lipids, aspartate/asparagine and nucleotide metabolism pathway differences associated with chloroquine resistance in Plasmodium vivax malaria

• Karan Uppal ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: marcuslacerda.br@gmail.com; kuppal2@emory.edu

  Affiliations Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America, Malaria Host–Pathogen Interaction Center, Atlanta, Georgia, United States of America

  http://orcid.org/0000-0001-5985-1668

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• Jorge L. Salinas,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Malaria Host–Pathogen Interaction Center, Atlanta, Georgia, United States of America, International Center for Malaria Research, Education and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia, United States of America, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

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• Wuelton M. Monteiro,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil

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• Fernando Val,

  Roles Data curation, Funding acquisition, Investigation, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliations Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil

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• Regina J. Cordy,

  Roles Data curation, Investigation, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

  Affiliations Malaria Host–Pathogen Interaction Center, Atlanta, Georgia, United States of America, International Center for Malaria Research, Education and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia, United States of America

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• Ken Liu,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America

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• Gisely C. Melo,

  Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil

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• Andre M. Siqueira,

  Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Instituto Nacional de Infectologia Evandro Chagas (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil

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• Belisa Magalhaes,

  Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil

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• Mary R. Galinski,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Malaria Host–Pathogen Interaction Center, Atlanta, Georgia, United States of America, International Center for Malaria Research, Education and Development, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, Georgia, United States of America, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

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• Marcus V. G. Lacerda ,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: marcuslacerda.br@gmail.com; kuppal2@emory.edu

  Affiliations Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Amazonas, Brazil, Instituto Leônidas & Maria Deane (FIOCRUZ), Manaus, Amazonas, Brazil

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• Dean P. Jones

  Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America, Malaria Host–Pathogen Interaction Center, Atlanta, Georgia, United States of America

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