Decreased complexity of glucose dynamics preceding the onset of diabetes in mice and rats

Xiaohua Douglas Zhang; David Pechter; Liming Yang; Xiaoli Ping; Zuliang Yao; Rumin Zhang; Xiaolan Shen; Nina Xiaoyan Li; Jonathan Connick; Andrea R. Nawrocki; Manu Chakravarthy; Cai Li

doi:10.1371/journal.pone.0182810

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Open Access

Peer-reviewed

Research Article

Decreased complexity of glucose dynamics preceding the onset of diabetes in mice and rats

Xiaohua Douglas Zhang ,

Contributed equally to this work with: Xiaohua Douglas Zhang, David Pechter

Roles Data curation, Formal analysis, Methodology, Writing – review & editing

Current address: Faculty of Health Sciences, University of Macau, Macao, China

Affiliation Department of BARDS, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
David Pechter ,

Contributed equally to this work with: Xiaohua Douglas Zhang, David Pechter

Roles Data curation, Formal analysis, Methodology, Visualization, Writing – review & editing

Affiliation Department of Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Liming Yang,

Roles Data curation, Formal analysis, Methodology, Resources

Affiliation Department of Diabetes, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Xiaoli Ping,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Laboratories Animal Resources, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Zuliang Yao,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources

Affiliation Department of Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Rumin Zhang,

Roles Conceptualization, Investigation, Methodology

Current address: Eternity Bioscience Inc., 2005 Eastpark Blvd., Cranbury, New Jersey, United States of America

Affiliation Department of Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Xiaolan Shen,

Roles Data curation, Investigation, Methodology, Resources

Affiliation Department of Laboratories Animal Resources, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Nina Xiaoyan Li,

Roles Conceptualization, Investigation, Methodology, Resources, Supervision

Affiliation Department of Diabetes, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Jonathan Connick,

Roles Conceptualization, Investigation, Methodology, Resources

Affiliation Department of Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Andrea R. Nawrocki,

Roles Methodology, Resources, Supervision, Visualization

Current address: Janssen Pharmaceutical, Spring House, Pennsylvania, United States of America

Affiliation Department of Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Manu Chakravarthy,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Translational Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, United States of America
⨯
Cai Li

Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: cai.li@merck.com

Affiliation Department of Pharmacology, Merck Research Laboratories, Kenilworth, New Jersey, United States of America

http://orcid.org/0000-0002-5132-1117

⨯

Decreased complexity of glucose dynamics preceding the onset of diabetes in mice and rats

Xiaohua Douglas Zhang,
David Pechter,
Liming Yang,
Xiaoli Ping,
Zuliang Yao,
Rumin Zhang,
Xiaolan Shen,
Nina Xiaoyan Li,
Jonathan Connick,
Andrea R. Nawrocki

Published: September 6, 2017
https://doi.org/10.1371/journal.pone.0182810

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