REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine

Jiaye Jiang; Zhongyuan Gan; Yuan Li; Wenqi Zhao; Hanqing Li; Jian-Pu Zheng; Yan Ke

doi:10.1371/journal.pone.0182746

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Open Access

Peer-reviewed

Research Article

REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine

Jiaye Jiang,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
⨯
Zhongyuan Gan,

Roles Formal analysis, Investigation

Affiliation Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
⨯
Yuan Li,

Roles Formal analysis, Investigation

Affiliation Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
⨯
Wenqi Zhao,

Roles Formal analysis, Investigation

Affiliation Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
⨯
Hanqing Li,

Roles Formal analysis, Investigation

Affiliation Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
⨯
Jian-Pu Zheng ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: keyantcm@163.com (YK); zhengjianpu@126.com (JPZ)

Affiliation Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China

http://orcid.org/0000-0001-9309-1439

⨯
Yan Ke

Roles Data curation, Funding acquisition, Project administration, Supervision

* E-mail: keyantcm@163.com (YK); zhengjianpu@126.com (JPZ)

Affiliation Experimental Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China
⨯

REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine

Jiaye Jiang,
Zhongyuan Gan,
Yuan Li,
Wenqi Zhao,
Hanqing Li,
Jian-Pu Zheng,
Yan Ke

Published: August 15, 2017
https://doi.org/10.1371/journal.pone.0182746

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