Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening

Natalia Platonova; Chiara Parravicini; Cristina Sensi; Alessandro Paoli; Michela Colombo; Antonino Neri; Ivano Eberini; Raffaella Chiaramonte

doi:10.1371/journal.pone.0182640

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Open Access

Peer-reviewed

Research Article

Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening

Natalia Platonova,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Health Sciences, Università degli Studi di Milano, Milano, Italy
⨯
Chiara Parravicini,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacy, Università degli Studi di Pisa, Pisa, Italy
⨯
Cristina Sensi,

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy
⨯
Alessandro Paoli,

Roles Investigation

Affiliation Department of Health Sciences, Università degli Studi di Milano, Milano, Italy
⨯
Michela Colombo,

Roles Conceptualization, Data curation, Investigation

Affiliation Department of Health Sciences, Università degli Studi di Milano, Milano, Italy
⨯
Antonino Neri,

Roles Funding acquisition, Methodology, Resources, Writing – review & editing

Affiliation Department of Oncology and Hemato-oncology, Università degli Studi di Milano; Hematology, Fondazione Cà Granda IRCCS Policlinico, Milano, Italy
⨯
Ivano Eberini ,

Contributed equally to this work with: Ivano Eberini, Raffaella Chiaramonte

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

* E-mail: ivano.eberini@unimi.it

Affiliation Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy

http://orcid.org/0000-0001-5521-3829

⨯
Raffaella Chiaramonte

Contributed equally to this work with: Ivano Eberini, Raffaella Chiaramonte

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Health Sciences, Università degli Studi di Milano, Milano, Italy
⨯

Identification of small molecules uncoupling the Notch::Jagged interaction through an integrated high-throughput screening

Natalia Platonova,
Chiara Parravicini,
Cristina Sensi,
Alessandro Paoli,
Michela Colombo,
Antonino Neri,
Ivano Eberini,
Raffaella Chiaramonte

Published: November 3, 2017
https://doi.org/10.1371/journal.pone.0182640

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Notch signaling
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Free energy
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Drug interactions
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Protein interactions
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High throughput screening
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Small molecules
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