Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism

Anabel Soldano; Sebastián Klinke; Lisandro H. Otero; Mario Rivera; Daniela L. Catalano-Dupuy; Eduardo A. Ceccarelli

doi:10.1371/journal.pone.0182535

Loading metrics

Open Access

Peer-reviewed

Research Article

Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism

Anabel Soldano,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
⨯
Sebastián Klinke,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Fundación Instituto Leloir, IIBBA-CONICET, and Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina
⨯
Lisandro H. Otero,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Fundación Instituto Leloir, IIBBA-CONICET, and Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina
⨯
Mario Rivera,

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – review & editing

Affiliation Department of Chemistry and Ralph N. Adams Institute for Bioanalytical Chemistry, University of Kansas, Lawrence, Kansas, United States of America
⨯
Daniela L. Catalano-Dupuy,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina
⨯
Eduardo A. Ceccarelli

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: ceccarelli@ibr-conicet.gov.ar

Affiliation Instituto de Biología Molecular y Celular de Rosario (IBR), CONICET, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

http://orcid.org/0000-0001-5776-3306

⨯

Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism

Anabel Soldano,
Sebastián Klinke,
Lisandro H. Otero,
Mario Rivera,
Daniela L. Catalano-Dupuy,
Eduardo A. Ceccarelli

Published: August 3, 2017
https://doi.org/10.1371/journal.pone.0182535

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Heme
Is the Subject Area "Heme" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Enzyme structure
Is the Subject Area "Enzyme structure" applicable to this article?

Thanks for your feedback.
Hydrogen bonding
Is the Subject Area "Hydrogen bonding" applicable to this article?

Thanks for your feedback.
Enzymes
Is the Subject Area "Enzymes" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.
Leptospira interrogans
Is the Subject Area "Leptospira interrogans" applicable to this article?

Thanks for your feedback.
Absorption spectra
Is the Subject Area "Absorption spectra" applicable to this article?

Thanks for your feedback.