Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6

• Sei-ichiro Ohkura,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Department of Physiology, Kanazawa University School of Medicine, Ishikawa, Japan, Department of System Biology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Soichiro Usui ,

  Contributed equally to this work with: Soichiro Usui, Noriko Takuwa

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of System Biology, Kanazawa University School of Medicine, Ishikawa, Japan

  http://orcid.org/0000-0003-1752-8082

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• Shin-ichiro Takashima,

  Roles Data curation, Investigation

  Affiliations Department of Physiology, Kanazawa University School of Medicine, Ishikawa, Japan, Department of System Biology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Noriko Takuwa ,

  Contributed equally to this work with: Soichiro Usui, Noriko Takuwa

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft

  Affiliations Department of Physiology, Kanazawa University School of Medicine, Ishikawa, Japan, Department of Health and Medical Sciences, Ishikawa Prefectural Nursing University, Ishikawa, Japan

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• Kazuaki Yoshioka,

  Roles Data curation, Investigation, Visualization

  Affiliation Department of Physiology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Yasuo Okamoto,

  Roles Data curation, Investigation

  Affiliation Department of Physiology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Yutaka Inagaki,

  Roles Methodology

  Affiliation Center for Matrix Biology and Medicine, Graduate School of Medicine, Tokai University, Kanagawa, Japan

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• Naotoshi Sugimoto,

  Roles Investigation

  Affiliation Department of Physiology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Teppei Kitano,

  Roles Investigation

  Affiliation Department of System Biology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Masayuki Takamura,

  Roles Supervision

  Affiliation Department of System Biology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Takashi Wada,

  Roles Methodology

  Affiliation Department of Nephrology and Laboratory Medicine, Kanazawa University School of Medicine, Ishikawa, Japan

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• Shuichi Kaneko,

  Roles Supervision

  Affiliation Department of System Biology, Kanazawa University School of Medicine, Ishikawa, Japan

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• Yoh Takuwa

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ytakuwa@med.kanazawa-u.ac.jp

  Affiliation Department of Physiology, Kanazawa University School of Medicine, Ishikawa, Japan

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