Massively parallel unsupervised single-particle cryo-EM data clustering via statistical manifold learning

• Jiayi Wu,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Institute of Condensed Matter Physics, School of Physics, Center for Quantitative Biology, Peking University, Beijing, China, Intel Parallel Computing Center for Structural Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Yong-Bei Ma,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software

  Affiliation Intel Parallel Computing Center for Structural Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Charles Congdon,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Software and Services Group, Intel Corporation, Santa Clara, California, United States of America

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• Bevin Brett,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Software and Services Group, Intel Corporation, Santa Clara, California, United States of America

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• Shuobing Chen,

  Roles Data curation, Validation

  Affiliations State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Institute of Condensed Matter Physics, School of Physics, Center for Quantitative Biology, Peking University, Beijing, China, Intel Parallel Computing Center for Structural Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Yaofang Xu,

  Roles Data curation, Formal analysis, Validation, Visualization

  Affiliations Intel Parallel Computing Center for Structural Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Biophysics, Peking University Health Science Center, Beijing, China

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• Qi Ouyang,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliations State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Institute of Condensed Matter Physics, School of Physics, Center for Quantitative Biology, Peking University, Beijing, China, Peking-Tsinghua Joint Center for Life Sciences, Peking University, Beijing, China

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• Youdong Mao

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: youdong_mao@dfci.harvard.edu

  Affiliations State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Institute of Condensed Matter Physics, School of Physics, Center for Quantitative Biology, Peking University, Beijing, China, Intel Parallel Computing Center for Structural Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America

  http://orcid.org/0000-0001-9302-2257

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