Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis

• Michael P. Gustafson,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Human Cellular Therapy Laboratory, Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

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• Nathan P. Staff,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Resources, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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• Svetlana Bornschlegl,

  Roles Data curation, Formal analysis, Validation, Visualization, Writing – review & editing

  Affiliation Human Cellular Therapy Laboratory, Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

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• Greg W. Butler,

  Roles Data curation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Human Cellular Therapy Laboratory, Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

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• Mary L. Maas,

  Roles Data curation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Human Cellular Therapy Laboratory, Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

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• Mohamed Kazamel,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Adeel Zubair,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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• Dennis A. Gastineau,

  Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  Affiliations Human Cellular Therapy Laboratory, Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, Department of Hematology, Mayo Clinic, Rochester, Minnesota, United States of America

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• Anthony J. Windebank,

  Roles Conceptualization, Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  Affiliation Department of Neurology, Mayo Clinic, Rochester, Minnesota, United States of America

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• Allan B. Dietz

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: dietz.allan@mayo.edu

  Affiliations Human Cellular Therapy Laboratory, Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

  http://orcid.org/0000-0003-3410-9621

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