Target specificity, in vivo pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma

• Peter Y. Yu ,

  Contributed equally to this work with: Peter Y. Yu, Heather L. Gardner

  Roles Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Medical Student Research Program, The Ohio State University College of Medicine, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America

  http://orcid.org/0000-0001-6084-2603

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• Heather L. Gardner ,

  Contributed equally to this work with: Peter Y. Yu, Heather L. Gardner

  Roles Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Veterinary Biosciences and Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America

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• Ryan Roberts,

  Roles Investigation, Methodology, Project administration, Resources, Supervision

  Affiliation Center for Childhood Cancer, Nationwide Children’s Hospital, Columbus, Ohio, United States of America

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• Hakan Cam,

  Roles Investigation, Project administration, Resources, Supervision

  Affiliation Center for Childhood Cancer, Nationwide Children’s Hospital, Columbus, Ohio, United States of America

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• Seethalakshmi Hariharan,

  Roles Investigation, Methodology

  Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America

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• Ling Ren,

  Roles Investigation

  Affiliation Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Amy K. LeBlanc,

  Roles Project administration, Supervision

  Affiliation Comparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Hui Xiao,

  Roles Investigation

  Affiliation Center for Childhood Cancer, Nationwide Children’s Hospital, Columbus, Ohio, United States of America

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• Jiayuh Lin,

  Roles Funding acquisition, Supervision

  Affiliation Center for Childhood Cancer, Nationwide Children’s Hospital, Columbus, Ohio, United States of America

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• Denis C. Guttridge,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Arthur G. James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America, Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America

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• Xiaokui Mo,

  Roles Formal analysis, Writing – review & editing

  Affiliation Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America

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• Chad E. Bennett,

  Roles Resources

  Affiliation Medicinal Chemistry Shared Resource, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America

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• Christopher C. Coss,

  Roles Investigation

  Affiliation Pharmacoanalytic Shared Resource, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America

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• Yonghua Ling,

  Roles Investigation, Project administration

  Affiliation Pharmacoanalytic Shared Resource, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America

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• Mitch A. Phelps,

  Roles Project administration, Resources, Supervision

  Affiliation Pharmacoanalytic Shared Resource, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States of America

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• Peter Houghton,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Greehey Children’s Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America

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•  [ ... ],
• Cheryl A. London

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: Cheryl.London@tufts.edu

  Affiliations Department of Veterinary Biosciences and Clinical Sciences, The Ohio State University, Columbus, Ohio, United States of America, Cummings School of Veterinary Medicine, Tufts University, Grafton, Massachusetts, United States of America

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