Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

Dahai Yu; Lin Lv; Li Fang; Bo Zhang; Junnan Wang; Ge Zhan; Lei Zhao; Xin Zhao; Baoxin Li

doi:10.1371/journal.pone.0181823

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Open Access

Peer-reviewed

Research Article

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

Dahai Yu ,

Contributed equally to this work with: Dahai Yu, Lin Lv

Roles Conceptualization, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Lin Lv ,

Contributed equally to this work with: Dahai Yu, Lin Lv

Roles Project administration, Software

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Li Fang,

Roles Project administration

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Bo Zhang,

Roles Project administration

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Junnan Wang,

Roles Project administration

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Ge Zhan,

Roles Project administration

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Lei Zhao,

Roles Project administration

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Xin Zhao,

Roles Conceptualization

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China
⨯
Baoxin Li

Roles Conceptualization, Funding acquisition

* E-mail: libx64@hotmail.com

Affiliation Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China

http://orcid.org/0000-0002-1680-3970

⨯

Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

Dahai Yu,
Lin Lv,
Li Fang,
Bo Zhang,
Junnan Wang,
Ge Zhan,
Lei Zhao,
Xin Zhao,
Baoxin Li

Published: August 1, 2017
https://doi.org/10.1371/journal.pone.0181823

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