Partial IGF-1 deficiency is sufficient to reduce heart contractibility, angiotensin II sensibility, and alter gene expression of structural and functional cardiac proteins

• José Luis González-Guerra ,

  Contributed equally to this work with: José Luis González-Guerra, Inma Castilla-Cortazar

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft

  Affiliation Escuela de Medicina, Tecnológico de Monterrey, Monterrey, México

  ⨯
• Inma Castilla-Cortazar ,

  Contributed equally to this work with: José Luis González-Guerra, Inma Castilla-Cortazar

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: iccortazar@itesm.mx

  Affiliations Escuela de Medicina, Tecnológico de Monterrey, Monterrey, México, Fundación de Investigación Hospitales de Madrid, HM Hospitales, Madrid, Spain

  http://orcid.org/0000-0002-2230-5927

  ⨯
• Gabriel A. Aguirre,

  Roles Formal analysis, Software, Writing – original draft, Writing – review & editing

  Affiliation Escuela de Medicina, Tecnológico de Monterrey, Monterrey, México

  ⨯
• Úrsula Muñoz,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Department of Medical Physiology, Faculty of Medicine, University CEU-San Pablo, Madrid, Spain

  ⨯
• Irene Martín-Estal,

  Roles Investigation

  Affiliation Escuela de Medicina, Tecnológico de Monterrey, Monterrey, México

  ⨯
• Elena Ávila-Gallego,

  Roles Investigation, Methodology

  Affiliation Department of Medical Physiology, Faculty of Medicine, University CEU-San Pablo, Madrid, Spain

  ⨯
• Miriam Granado,

  Roles Formal analysis, Investigation

  Affiliation Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain

  ⨯
• Juan E. Puche,

  Roles Investigation, Methodology

  Affiliations Department of Medical Physiology, Faculty of Medicine, University CEU-San Pablo, Madrid, Spain, Department of Cardiology, Hospital Universitario Puerta del Mar, Cádiz, Spain

  ⨯
• Ángel Luis García-Villalón

  Roles Conceptualization, Formal analysis, Investigation

  Affiliation Department of Physiology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain

  ⨯