Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells

Chengyan Jin; Guangxin Zhang; Yifan Zhang; Peiyan Hua; Ge Song; Mei Sun; Xin Li; Ti Tong; Bingjin Li; Xingyi Zhang

doi:10.1371/journal.pone.0181731

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Open Access

Peer-reviewed

Research Article

Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells

Chengyan Jin,

Roles Data curation, Formal analysis

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Guangxin Zhang,

Roles Investigation, Methodology, Project administration

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Yifan Zhang,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Peiyan Hua,

Roles Conceptualization, Data curation

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Ge Song,

Roles Conceptualization

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Mei Sun,

Roles Writing – review & editing

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Xin Li,

Roles Writing – review & editing

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Ti Tong ,

Roles Writing – review & editing

* E-mail: xingyizhang@live.com (XYZ); libingjin@jlu.edu.cn (BJL); tti666@163.com (TT)

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Bingjin Li ,

Roles Conceptualization, Data curation

* E-mail: xingyizhang@live.com (XYZ); libingjin@jlu.edu.cn (BJL); tti666@163.com (TT)

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China
⨯
Xingyi Zhang

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: xingyizhang@live.com (XYZ); libingjin@jlu.edu.cn (BJL); tti666@163.com (TT)

Affiliation Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, P.R. China

http://orcid.org/0000-0001-8390-6585

⨯

Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells

Chengyan Jin,
Guangxin Zhang,
Yifan Zhang,
Peiyan Hua,
Ge Song,
Mei Sun,
Xin Li,
Ti Tong,
Bingjin Li,
Xingyi Zhang

Published: August 4, 2017
https://doi.org/10.1371/journal.pone.0181731

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Apoptosis
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Cell cycle and cell division
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Lung and intrathoracic tumors
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Cell staining
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Flow cytometry
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Reactive oxygen species
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