Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity

Gui-Mei Kong; Min Yu; Zhongping Gu; Zhi Chen; Rui-Ming Xu; Deon O'Bryant; Zhengxin Wang

doi:10.1371/journal.pone.0181601

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Open Access

Peer-reviewed

Research Article

Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity

Gui-Mei Kong,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Medical School of Yangzhou University, Yangzhou, China
⨯
Min Yu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation School of Life Sciences, Yunnan University, Yunnan, China
⨯
Zhongping Gu,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China
⨯
Zhi Chen,

Roles Formal analysis, Software

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China
⨯
Rui-Ming Xu,

Roles Formal analysis, Software

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing, China
⨯
Deon O'Bryant,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Department of Biological Sciences, Clark Atlanta University, Atlanta, GA, United States of America
⨯
Zhengxin Wang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: zwang@cau.edu

Affiliation Department of Biological Sciences, Clark Atlanta University, Atlanta, GA, United States of America

http://orcid.org/0000-0002-7721-7326

⨯

Selective small-chemical inhibitors of protein arginine methyltransferase 5 with anti-lung cancer activity

Gui-Mei Kong,
Min Yu,
Zhongping Gu,
Zhi Chen,
Rui-Ming Xu,
Deon O'Bryant,
Zhengxin Wang

Published: August 14, 2017
https://doi.org/10.1371/journal.pone.0181601

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Lung and intrathoracic tumors
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Methylation
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Cancer treatment
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Arginine
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Histones
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Secondary lung tumors
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Methyltransferases
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Library screening
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