Functional differences between PD-1⁺ and PD-1^- CD4⁺ effector T cells in healthy donors and patients with glioblastoma multiforme

• Brittany A. Goods ,

  Contributed equally to this work with: Brittany A. Goods, Amanda L. Hernandez, Daniel E. Lowther

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Departments of Biological Engineering and Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

  http://orcid.org/0000-0002-5962-9570

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• Amanda L. Hernandez ,

  Contributed equally to this work with: Brittany A. Goods, Amanda L. Hernandez, Daniel E. Lowther

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Daniel E. Lowther ,

  Contributed equally to this work with: Brittany A. Goods, Amanda L. Hernandez, Daniel E. Lowther

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Liliana E. Lucca,

  Roles Data curation, Formal analysis

  Affiliation Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Benjamin A. Lerner,

  Roles Data curation, Formal analysis

  Affiliation Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Murat Gunel,

  Roles Investigation

  Affiliations Department of Genetics, Yale School of Medicine, New Haven, Connecticut, United States of America, Department of Neurosurgery, Yale School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Khadir Raddassi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliation Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America

  ⨯
• Vlad Coric,

  Roles Conceptualization, Funding acquisition, Resources

  Affiliation Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

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• David A. Hafler ,

  Roles Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Departments of Neurology and Immunobiology, Yale School of Medicine, New Haven, Connecticut, United States of America, The Broad Institute of MIT and Harvard, Cambridge, MA, United States of America

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• J. Christopher Love

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: clove@mit.edu

  ¶‡ These authors also contributed equally to this work.

  Affiliations Departments of Biological Engineering and Chemical Engineering, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, The Broad Institute of MIT and Harvard, Cambridge, MA, United States of America

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