Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage

María Celeste Nicolao; Julia A. Loos; Christian Rodriguez Rodrigues; Viviana Beas; Andrea C. Cumino

doi:10.1371/journal.pone.0181528

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Research Article

Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage

María Celeste Nicolao,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes, Nivel Cero, Mar del Plata, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
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Julia A. Loos,

Roles Formal analysis, Investigation

Affiliations Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes, Nivel Cero, Mar del Plata, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
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Christian Rodriguez Rodrigues,

Roles Investigation, Visualization, Writing – review & editing

Affiliations Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina, Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes, Nivel 2, Mar del Plata, Argentina
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Viviana Beas,

Roles Resources

Affiliations Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes, Nivel 2, Mar del Plata, Argentina, Hospital Privado de Comunidad, Mar del Plata, Buenos Aires, Argentina
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Andrea C. Cumino

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: acumino@gmail.com

Affiliations Laboratorio de Zoonosis Parasitarias, Departamento de Biología, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes, Nivel Cero, Mar del Plata, Argentina, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina, Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes, Nivel 2, Mar del Plata, Argentina

http://orcid.org/0000-0002-0225-6363

⨯

Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage

María Celeste Nicolao,
Julia A. Loos,
Christian Rodriguez Rodrigues,
Viviana Beas,
Andrea C. Cumino

Published: August 17, 2017
https://doi.org/10.1371/journal.pone.0181528

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Autophagic cell death
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Larvae
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Cestodes
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Echinococcus
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Endoplasmic reticulum
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Drug therapy
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