Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells

Ryo Matoba; Yuki Morizane; Yusuke Shiode; Masayuki Hirano; Shinichiro Doi; Shinji Toshima; Ryoichi Araki; Mika Hosogi; Tomoko Yonezawa; Fumio Shiraga

doi:10.1371/journal.pone.0181481

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Open Access

Peer-reviewed

Research Article

Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells

Ryo Matoba,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yuki Morizane ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: moriza-y@okayama-u.ac.jp

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Yusuke Shiode,

Roles Conceptualization, Data curation, Investigation, Supervision, Validation

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Masayuki Hirano,

Roles Conceptualization, Data curation, Investigation, Methodology, Supervision, Validation

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shinichiro Doi,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Shinji Toshima,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Ryoichi Araki,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Mika Hosogi,

Roles Conceptualization, Data curation, Investigation, Validation

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Tomoko Yonezawa,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Resources, Supervision, Validation

Affiliation Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯
Fumio Shiraga

Roles Conceptualization, Methodology, Project administration, Supervision, Validation

Affiliation Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
⨯

Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells

Ryo Matoba,
Yuki Morizane,
Yusuke Shiode,
Masayuki Hirano,
Shinichiro Doi,
Shinji Toshima,
Ryoichi Araki,
Mika Hosogi,
Tomoko Yonezawa,
Fumio Shiraga

Published: July 18, 2017
https://doi.org/10.1371/journal.pone.0181481

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Phosphorylation
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MAPK signaling cascades
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SMAD signaling
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Cytokines
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DAPI staining
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Enzyme-linked immunoassays
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Epithelial cells
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Protein kinases
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