Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

Akito Ono; Osamu Sano; Ken-ichi Kazetani; Takamichi Muraki; Keisuke Imamura; Hiroyuki Sumi; Junji Matsui; Hidehisa Iwata

doi:10.1371/journal.pone.0181243

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Open Access

Peer-reviewed

Research Article

Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

Akito Ono,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan

http://orcid.org/0000-0002-8518-2813

⨯
Osamu Sano,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
⨯
Ken-ichi Kazetani,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – original draft

Affiliation Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
⨯
Takamichi Muraki,

Roles Resources, Writing – original draft

Affiliation Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
⨯
Keisuke Imamura,

Roles Resources, Writing – original draft

Affiliation Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
⨯
Hiroyuki Sumi,

Roles Conceptualization, Methodology, Writing – original draft

Current address: Medical Science, Medical affairs, Celgene K.K., Tokyo, Japan

Affiliation Oncology Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
⨯
Junji Matsui,

Roles Funding acquisition, Project administration, Supervision, Writing – original draft

Affiliation Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan
⨯
Hidehisa Iwata

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hidehisa.iwata@takeda.com

Affiliation Biomolecular Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Fujisawa, Kanagawa, Japan

http://orcid.org/0000-0002-0950-6388

⨯

Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition

Akito Ono,
Osamu Sano,
Ken-ichi Kazetani,
Takamichi Muraki,
Keisuke Imamura,
Hiroyuki Sumi,
Junji Matsui,
Hidehisa Iwata

Published: July 13, 2017
https://doi.org/10.1371/journal.pone.0181243

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