New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres

• Mohamed I. Attia ,

  Roles Conceptualization, Data curation, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mattia@ksu.edu.sa (MIA); hatem_741@yahoo.com (HAA)

  Affiliations Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre (ID: 60014618), Dokki, Giza, Egypt

  http://orcid.org/0000-0002-5019-6086

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• Wagdy M. Eldehna,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

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• Samar A. Afifi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Pharmaceutics, National Organization for Drug Control and Research, Giza, Egypt, Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

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• Adam B. Keeton,

  Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, United States of America

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• Gary A. Piazza,

  Roles Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Oncologic Sciences and Pharmacology, Drug Discovery Research Center, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, United States of America

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• Hatem A. Abdel-Aziz

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: mattia@ksu.edu.sa (MIA); hatem_741@yahoo.com (HAA)

  Affiliation Department of Applied Organic Chemistry, National Res earch Centre, (ID: 60014618), Dokki, Giza, Egypt

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