Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth

Mark C. Weir; Sabine Hellwig; Li Tan; Yao Liu; Nathanael S. Gray; Thomas E. Smithgall

doi:10.1371/journal.pone.0181178

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Open Access

Peer-reviewed

Research Article

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD⁺ AML cell growth

Mark C. Weir,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Sabine Hellwig,

Roles Conceptualization, Investigation, Methodology

Current address: ARUP Laboratories, Salt Lake City, Utah, United States of America

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Li Tan,

Roles Conceptualization, Investigation, Methodology

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Yao Liu,

Roles Investigation, Methodology, Resources

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Nathanael S. Gray,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Thomas E. Smithgall

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: tsmithga@pitt.edu

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-5238-3806

⨯

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD⁺ AML cell growth

Mark C. Weir,
Sabine Hellwig,
Li Tan,
Yao Liu,
Nathanael S. Gray,
Thomas E. Smithgall

Published: July 20, 2017
https://doi.org/10.1371/journal.pone.0181178

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In vitro kinase assay
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Apoptosis
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Bone marrow cells
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Immunoprecipitation
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Acute myeloid leukemia
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Tyrosine kinases
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Cell growth
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Protein kinases
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