Inactivation of human DGAT2 by oxidative stress on cysteine residues

Sunhee Jung; Miri Choi; Kwangman Choi; Eun Bin Kwon; Mingu Kang; Dong-eun Kim; Hyejeong Jeong; Janghwan Kim; Jong Heon Kim; Mun Ock Kim; Sang-Bae Han; Sungchan Cho

doi:10.1371/journal.pone.0181076

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Peer-reviewed

Research Article

Inactivation of human DGAT2 by oxidative stress on cysteine residues

Sunhee Jung ,

Contributed equally to this work with: Sunhee Jung, Miri Choi

Affiliations Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea, College of Pharmacy, Chungbuk National University, 1 Chungdae-ro Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Miri Choi ,

Contributed equally to this work with: Sunhee Jung, Miri Choi

Affiliations Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea, College of Pharmacy, Chungbuk National University, 1 Chungdae-ro Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Kwangman Choi,

Affiliation Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Eun Bin Kwon,

Affiliations College of Pharmacy, Chungbuk National University, 1 Chungdae-ro Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea, Natural Medicine Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Mingu Kang,

Affiliations Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea, College of Pharmacy, Chungbuk National University, 1 Chungdae-ro Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Dong-eun Kim,

Affiliations Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea, College of Pharmacy, Chungbuk National University, 1 Chungdae-ro Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Hyejeong Jeong,

Affiliations Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea, College of Pharmacy, Chungbuk National University, 1 Chungdae-ro Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Janghwan Kim,

Affiliation Stem Cell Research Center, Korea Research Institute of Bioscience & Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, South Korea
⨯
Jong Heon Kim,

Affiliation Cancer Cell and Molecular Biology Branch, Research Institute, National Cancer Center, Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, South Korea
⨯
Mun Ock Kim,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Sang-Bae Han,

Affiliation College of Pharmacy, Chungbuk National University, 1 Chungdae-ro Seowon-gu, Cheongju-si, Chungcheongbuk-do, South Korea
⨯
Sungchan Cho

* E-mail: sungchan@kribb.re.kr

Affiliations Anticancer Agent Research Center, Korea Research Institute of Bioscience & Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gu, Cheongju-si, Chungcheongbuk-do, South Korea, Department of Biomolecular Science, Korea University of Science and Technology, 217 Gajeong-ro, Daejeon, South Korea

http://orcid.org/0000-0001-7627-978X

⨯

Inactivation of human DGAT2 by oxidative stress on cysteine residues

Sunhee Jung,
Miri Choi,
Kwangman Choi,
Eun Bin Kwon,
Mingu Kang,
Dong-eun Kim,
Hyejeong Jeong,
Janghwan Kim,
Jong Heon Kim,
Mun Ock Kim

Published: July 11, 2017
https://doi.org/10.1371/journal.pone.0181076

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