A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system

• Cristina St. Pierre ,

  Contributed equally to this work with: Cristina St. Pierre, Jane Guo, John D. Shin

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Jane Guo ,

  Contributed equally to this work with: Cristina St. Pierre, Jane Guo, John D. Shin

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• John D. Shin ,

  Contributed equally to this work with: Cristina St. Pierre, Jane Guo, John D. Shin

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Laura W. Engstrom,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Hyun-Hee Lee,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Alan Herbert,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Genetics and Pharmacogenomics, Merck Research Laboratories, Boston, MA, United States of America

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• Laura Surdi,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Boston, MA, United States of America

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• James Baker,

  Roles Data curation, Supervision, Validation, Writing – review & editing

  Affiliation Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Boston, MA, United States of America

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• Michael Salmon,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Sanjiv Shah,

  Roles Resources, Validation, Visualization, Writing – review & editing

  Affiliation Pharmacology, Merck Research Laboratories, Boston, MA, United States of America

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• J. Michael Ellis,

  Roles Resources, Validation, Writing – review & editing

  Affiliation Exploratory Chemistry, Merck Research Laboratories, Boston, MA, United States of America

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• Hani Houshyar,

  Roles Conceptualization, Data curation, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  Current address: Biogen, Cambridge, MA, United States of America

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Michael A. Crackower,

  Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Current address: Celgene, Cambridge, MA, United States of America

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Melanie A. Kleinschek,

  Roles Conceptualization, Writing – review & editing

  Current address: Theravance Biopharma, San Francisco, CA, United States of America

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Dallas C. Jones,

  Roles Conceptualization, Writing – review & editing

  Current address: Abide Therapeutics, San Diego, CA, United States of America

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Alexandra Hicks,

  Roles Conceptualization, Resources, Supervision, Validation, Visualization, Writing – review & editing

  Current address: Oncorus, Cambridge, MA, United States of America

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Dennis M. Zaller,

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

  Current address: Celgene, Cambridge, MA, United States of America

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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• Stephen E. Alves,

  Roles Conceptualization, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

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•  [ ... ],
• Ravisankar A. Ramadas

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ramadas.pubmed@gmail.com

  Current address: Jounce Therapeutics, Cambridge, MA, United States of America

  Affiliation Oncology & Immunology Discovery, Merck Research Laboratories, Boston, MA, United States of America

  http://orcid.org/0000-0001-9053-6711

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