Influence of lung CT changes in chronic obstructive pulmonary disease (COPD) on the human lung microbiome

• Marion Engel ,

  Contributed equally to this work with: Marion Engel, David Endesfelder

  Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: marion.engel@helmholtz-muenchen.de

  Affiliations Scientific Computing Research Unit, Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, Research Unit Comparative Microbiome Analysis, Helmholtz Zentrum München, Neuherberg, Germany

  http://orcid.org/0000-0002-0741-8931

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• David Endesfelder ,

  Contributed equally to this work with: Marion Engel, David Endesfelder

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Bundesamt für Strahlenschutz, Fachbereich Strahlenschutz und Gesundheit, Oberschleißheim, Germany

  Affiliation Scientific Computing Research Unit, Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany

  ⨯
• Brigitte Schloter-Hai,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Research Unit Comparative Microbiome Analysis, Helmholtz Zentrum München, Neuherberg, Germany

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• Susanne Kublik,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Research Unit Comparative Microbiome Analysis, Helmholtz Zentrum München, Neuherberg, Germany

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• Michael S. Granitsiotis,

  Roles Formal analysis, Investigation, Writing – review & editing

  Current address: Joint Genome Institute, Walnut Creek, CA, United States of America

  Affiliation Research Unit Comparative Microbiome Analysis, Helmholtz Zentrum München, Neuherberg, Germany

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• Piera Boschetto,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medical Sciences, University of Ferrara, Ferrara, Italy

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• Mariarita Stendardo,

  Roles Resources, Writing – review & editing

  Affiliation Department of Medical Sciences, University of Ferrara, Ferrara, Italy

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• Imre Barta,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary

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• Balazs Dome,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary

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• Jean-François Deleuze,

  Roles Resources, Writing – review & editing

  Affiliation Centre National de Génotypage, Institut de Génomique, CEA, Evry, France

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• Anne Boland,

  Roles Resources, Writing – review & editing

  Affiliation Centre National de Génotypage, Institut de Génomique, CEA, Evry, France

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• Joachim Müller-Quernheim,

  Roles Resources, Writing – review & editing

  Affiliation Department of Pneumology, University Medical Center, Freiburg, Germany

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• Antje Prasse,

  Roles Resources, Writing – review & editing

  Affiliations Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, Member of the German Center for Lung Research (DZL), Giessen, Germany

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• Tobias Welte,

  Roles Resources, Writing – review & editing

  Affiliations Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, Member of the German Center for Lung Research (DZL), Giessen, Germany

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• Jens Hohlfeld,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany, Member of the German Center for Lung Research (DZL), Giessen, Germany, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

  ⨯
• Deepak Subramanian,

  Roles Resources, Writing – review & editing

  Affiliation Department of Respiratory Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom

  ⨯
• David Parr,

  Roles Resources, Writing – review & editing

  Affiliation Department of Respiratory Medicine, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, United Kingdom

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• Ivo Glynne Gut,

  Roles Resources, Writing – review & editing

  Affiliation CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute for Science and Technology, Barcelona, Spain

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• Timm Greulich,

  Roles Resources, Writing – review & editing

  Affiliations Member of the German Center for Lung Research (DZL), Giessen, Germany, Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg Philipps-University, Marburg, Germany

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• Andreas Rembert Koczulla,

  Roles Resources, Writing – review & editing

  Affiliations Member of the German Center for Lung Research (DZL), Giessen, Germany, Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg Philipps-University, Marburg, Germany

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• Adam Nowinski,

  Roles Resources, Writing – review & editing

  Affiliation Second Department of Respiratory Medicine, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland

  ⨯
• Dorota Gorecka,

  Roles Resources, Writing – review & editing

  Affiliation Second Department of Respiratory Medicine, National Tuberculosis and Lung Diseases Research Institute, Warsaw, Poland

  ⨯
• Dave Singh,

  Roles Resources, Writing – review & editing

  Affiliation University of Manchester, Medicines Evaluation Unit and University Hospital of South Manchester Foundation Trust, Manchester, United Kingdom

  ⨯
• Sumit Gupta,

  Roles Resources, Writing – review & editing

  Affiliation Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

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• Christopher E. Brightling,

  Roles Resources, Writing – review & editing

  Affiliation Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom

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• Harald Hoffmann,

  Roles Formal analysis, Methodology, Resources, Writing – review & editing

  Affiliation Institute of Microbiology and Laboratory Medicine, Synlab MVZ Gauting & IML red GmbH, Gauting, Germany

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• Marion Frankenberger,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation CPC Comprehensive Pneumology Center, Helmholtz Zentrum München, Ludwig-Maximilians Universität und Asklepios Klinik Gauting, Munich, Germany

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• Thomas P. Hofer,

  Roles Resources, Writing – review & editing

  Affiliation EvA Study Center, Helmholtz Zentrum Muenchen, Gauting, Germany

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• Dorothe Burggraf,

  Roles Resources, Writing – review & editing

  Affiliation EvA Study Center, Helmholtz Zentrum Muenchen, Gauting, Germany

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• Marion Heiss-Neumann,

  Roles Resources, Writing – review & editing

  Affiliation EvA Study Center, Helmholtz Zentrum Muenchen, Gauting, Germany

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• Loems Ziegler-Heitbrock,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – review & editing

  Affiliation EvA Study Center, Helmholtz Zentrum Muenchen, Gauting, Germany

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• Michael Schloter ,

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Research Unit Comparative Microbiome Analysis, Helmholtz Zentrum München, Neuherberg, Germany

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•  [ ... ],
• Wolfgang zu Castell

  Roles Formal analysis, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliations Scientific Computing Research Unit, Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, Department of Mathematics, Technische Universität München, Munich, Germany

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