RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

Danielle Kamato; Venkata Vijayanand Bhaskarala; Nitin Mantri; Tae Gyu Oh; Dora Ling; Reearna Janke; Wenhua Zheng; Peter J Little; Narin Osman

doi:10.1371/journal.pone.0180842

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Open Access

Peer-reviewed

Research Article

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

Danielle Kamato ,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: d.kamato@uq.edu.au

Affiliation School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia

http://orcid.org/0000-0002-1089-2829

⨯
Venkata Vijayanand Bhaskarala,

Roles Data curation, Formal analysis, Investigation, Software, Validation

Affiliation Department of Biotechnology and Environmental Biology, School of Applied Sciences, RMIT University, Bundoora, VIC, Australia
⨯
Nitin Mantri,

Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Department of Biotechnology and Environmental Biology, School of Applied Sciences, RMIT University, Bundoora, VIC, Australia
⨯
Tae Gyu Oh,

Roles Data curation, Formal analysis, Software

Affiliation Institute for Molecular Bioscience, The University of Queensland, St Lucia, Qld, Australia
⨯
Dora Ling,

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia
⨯
Reearna Janke,

Roles Data curation, Formal analysis, Investigation, Validation

Affiliation School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia
⨯
Wenhua Zheng,

Roles Conceptualization, Project administration, Writing – review & editing

Affiliation Faculty of Health Sciences, University of Macau, Taipa, China
⨯
Peter J Little,

Roles Conceptualization, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia, Xinhua College of Sun Yat-sen University, Tianhe District, Guangzhou, China
⨯
Narin Osman

Roles Conceptualization, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Pharmacy, The University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia, Diabetes Complications Group, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia, Monash University, Departments of Medicine and Immunology, Central and Eastern Clinical School, Alfred Health, Melbourne, VIC, Australia
⨯

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells

Danielle Kamato,
Venkata Vijayanand Bhaskarala,
Nitin Mantri,
Tae Gyu Oh,
Dora Ling,
Reearna Janke,
Wenhua Zheng,
Peter J Little,
Narin Osman

Published: July 18, 2017
https://doi.org/10.1371/journal.pone.0180842

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Gene regulation
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Transactivation
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Thrombin
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Gene expression
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Thrombin signaling
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G protein coupled receptors
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Receptor antagonist therapy
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Genomic signal processing
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