Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification

Klazina Kooiman; Tom van Rooij; Bin Qin; Frits Mastik; Hendrik J. Vos; Michel Versluis; Alexander L. Klibanov; Nico de Jong; Flordeliza S. Villanueva; Xucai Chen

doi:10.1371/journal.pone.0180747

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Open Access

Peer-reviewed

Research Article

Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification

Klazina Kooiman ,

* E-mail: k.kooiman@erasmusmc.nl

Affiliations Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America, Netherlands Heart Institute, Utrecht, the Netherlands, Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands

http://orcid.org/0000-0002-0607-4989

⨯
Tom van Rooij,

Affiliation Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands
⨯
Bin Qin,

Affiliation Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Frits Mastik,

Affiliation Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands
⨯
Hendrik J. Vos,

Affiliations Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands, Laboratory of Acoustical Wavefield Imaging, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands
⨯
Michel Versluis,

Affiliation Physics of Fluids Group, MIRA Institute for Biomedical Technology and Technical Medicine and MESA+ Institute for Nanotechnology, University of Twente, Enschede, the Netherlands
⨯
Alexander L. Klibanov,

Affiliation Cardiovascular Division, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America
⨯
Nico de Jong,

Affiliations Department of Biomedical Engineering, Thoraxcenter, Erasmus MC, Rotterdam, the Netherlands, Laboratory of Acoustical Wavefield Imaging, Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands
⨯
Flordeliza S. Villanueva,

Affiliation Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯
Xucai Chen

Affiliation Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America
⨯

Focal areas of increased lipid concentration on the coating of microbubbles during short tone-burst ultrasound insonification

Klazina Kooiman,
Tom van Rooij,
Bin Qin,
Frits Mastik,
Hendrik J. Vos,
Michel Versluis,
Alexander L. Klibanov,
Nico de Jong,
Flordeliza S. Villanueva,
Xucai Chen

Published: July 7, 2017
https://doi.org/10.1371/journal.pone.0180747

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