Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response

• Nicoletta Di Simone ,

  Contributed equally to this work with: Nicoletta Di Simone, Fiorella Di Nicuolo

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft

  Affiliation Department of Obstetrics and Gynecology, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy

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• Fiorella Di Nicuolo ,

  Contributed equally to this work with: Nicoletta Di Simone, Fiorella Di Nicuolo

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations Department of Obstetrics and Gynecology, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy, International Scientific Institute Paolo VI, ISI, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy

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• Riccardo Marana,

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliations Department of Obstetrics and Gynecology, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy, International Scientific Institute Paolo VI, ISI, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy

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• Roberta Castellani,

  Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

  Affiliation Department of Obstetrics and Gynecology, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy

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• Francesco Ria,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Institute of General Pathology, Università Cattolica Del Sacro Cuore, Rome, Italy

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• Manuela Veglia,

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliation Department of Obstetrics and Gynecology, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy

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• Giovanni Scambia,

  Roles Conceptualization, Data curation, Formal analysis, Methodology

  Affiliation Department of Obstetrics and Gynecology, Università Cattolica Del Sacro Cuore, A. Gemelli Universitary Hospital, Rome, Italy

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• Daniel Surbek,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Supervision

  Affiliation Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland

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• Eytan Barnea ,

  Roles Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft

  ¶‡ These authors also contributed equally to this work.

  Affiliations The Society for the Investigation of Early Pregnancy (SIEP), Cherry Hill, New Jersey, United States of America, BioIncept LLC, Cherry Hill, New Jersey, United States of America

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• Martin Mueller

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: martin.mueller@insel.ch

  ¶‡ These authors also contributed equally to this work.

  Affiliations Department of Obstetrics and Gynecology, University Hospital Bern, Bern, Switzerland, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0001-5594-0532

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