An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII

• Behnaz Pezeshkpoor ,

  Contributed equally to this work with: Behnaz Pezeshkpoor, Ursula Schreck, Arijit Biswas

  Affiliations Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany, Center for Rare Diseases Bonn (ZSEB), University Clinic Bonn, Bonn, Germany

  http://orcid.org/0000-0002-4796-3424

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• Ursula Schreck ,

  Contributed equally to this work with: Behnaz Pezeshkpoor, Ursula Schreck, Arijit Biswas

  Affiliations Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany, Center for Rare Diseases Bonn (ZSEB), University Clinic Bonn, Bonn, Germany

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• Arijit Biswas ,

  Contributed equally to this work with: Behnaz Pezeshkpoor, Ursula Schreck, Arijit Biswas

  Affiliations Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany, Center for Rare Diseases Bonn (ZSEB), University Clinic Bonn, Bonn, Germany

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• Julia Driesen,

  Affiliation Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany

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• Ann-Cristin Berkemeier,

  Affiliations Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany, Center for Rare Diseases Bonn (ZSEB), University Clinic Bonn, Bonn, Germany

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• Anna Pavlova,

  Affiliations Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany, Center for Rare Diseases Bonn (ZSEB), University Clinic Bonn, Bonn, Germany

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• Jens Müller,

  Affiliations Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany, Center for Rare Diseases Bonn (ZSEB), University Clinic Bonn, Bonn, Germany

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• Johannes Oldenburg

  * E-mail: Johannes.Oldenburg@ukbonn.de

  Affiliations Institute of Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany, Center for Rare Diseases Bonn (ZSEB), University Clinic Bonn, Bonn, Germany

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