Sample size determination for a specific region in multiregional clinical trials with multiple co-primary endpoints

• Wong-Shian Huang,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan, Institute of Population Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan

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• Hui-Nien Hung,

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan

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• Toshimitsu Hamasaki,

  Roles Conceptualization, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  Affiliation National Cerebral and Cardiovascular Center, Osaka, Japan

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• Chin-Fu Hsiao

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: chinfu@nhri.org.tw

  Affiliations Institute of Statistics, National Chiao Tung University, Hsinchu, Taiwan, Institute of Population Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan

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