Generation of an artificial human B cell line test system using Transpo-mAb^TM technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins

• Diana Klose,

  Affiliations Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany, Department of Experimental Medicine and Immunotherapy, Institute for Applied Medical Engineering, University Hospital RWTH Aachen, Aachen, Germany

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• Mira Woitok,

  Affiliations Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany, Institute of Molecular Biotechnology (Biology VII), RWTH Aachen University, Aachen, Germany

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• Judith Niesen,

  Affiliation Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany

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• Roger R. Beerli,

  Affiliation NBE-Therapeutics AG, Basel, Switzerland

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• Ulf Grawunder,

  Affiliation NBE-Therapeutics AG, Basel, Switzerland

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• Rainer Fischer,

  Affiliations Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany, Institute of Molecular Biotechnology (Biology VII), RWTH Aachen University, Aachen, Germany

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• Stefan Barth,

  Affiliations Department of Experimental Medicine and Immunotherapy, Institute for Applied Medical Engineering, University Hospital RWTH Aachen, Aachen, Germany, South African Research Chair in Cancer Biotechnology, Institute of Infectious Disease and Molecular Medicine (IDM), Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

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• Rolf Fendel ,

  Contributed equally to this work with: Rolf Fendel, Thomas Nachreiner

  * E-mail: rolf.fendel@ime.fraunhofer.de

  Affiliation Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany

  http://orcid.org/0000-0003-4716-0311

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• Thomas Nachreiner

  Contributed equally to this work with: Rolf Fendel, Thomas Nachreiner

  Affiliation Department of Experimental Medicine and Immunotherapy, Institute for Applied Medical Engineering, University Hospital RWTH Aachen, Aachen, Germany

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