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Open Access

Peer-reviewed

Research Article

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy

Hui Xiao,

Affiliation Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, United States of America
⨯
Hemant Kumar Bid,

Affiliation Resonant Therapeutics, Inc. Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, United States of America
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Xiang Chen,

Affiliation Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Xiaojuan Wu,

Affiliation Department of Pediatric Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
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Jia Wei,

Affiliation Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
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Yang Bian,

Affiliation Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children’s Hospital, Columbus, Ohio, United States of America
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Chengguang Zhao,

Affiliation Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, University Town, Wenzhou, Zhejiang, People's Republic of China
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Huameng Li,

Affiliation Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, United States of America
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Chenglong Li,

Affiliation College of Pharmacy, the University of Florida, Gainesville, Florida, United States of America
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Jiayuh Lin

* E-mail: JLin@som.umaryland.edu

Affiliation Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
⨯

Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy

Hui Xiao,
Hemant Kumar Bid,
Xiang Chen,
Xiaojuan Wu,
Jia Wei,
Yang Bian,
Chengguang Zhao,
Huameng Li,
Chenglong Li,
Jiayuh Lin

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Published: July 3, 2017
https://doi.org/10.1371/journal.pone.0180297

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Rhabdomyosarcoma
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Cancer treatment
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Phosphorylation
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Signal inhibition
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Cancers and neoplasms
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STAT signaling
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Malignant tumors
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Angiogenesis
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