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Open Access

Peer-reviewed

Research Article

The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Asma Begum,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Theodore Ewachiw,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Clinton Jung,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Ally Huang,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
K. Jessica Norberg,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Luigi Marchionni,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Ross McMillan,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Vesselin Penchev,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
N. V. Rajeshkumar,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Anirban Maitra,

Affiliation Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Laura Wood,

Affiliation Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Chenguang Wang,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Christopher Wolfgang,

Affiliation Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Ana DeJesus-Acosta,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Daniel Laheru,

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Irina M. Shapiro,

Affiliation Verastem, Inc., Needham, Massachusetts, United States of America
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Mahesh Padval,

Affiliation Verastem, Inc., Needham, Massachusetts, United States of America
⨯
Jonathan A. Pachter,

Affiliation Verastem, Inc., Needham, Massachusetts, United States of America
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David T. Weaver,

Affiliation Verastem, Inc., Needham, Massachusetts, United States of America
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Zeshaan A. Rasheed,

Current address: One Medimmune Way, Gaithersburg, Maryland, United States of America

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
[ ... ],
William Matsui

* E-mail: matsuwi@jhmi.edu

Affiliation Departments of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

http://orcid.org/0000-0002-3088-0964

⨯
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The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma

Asma Begum,
Theodore Ewachiw,
Clinton Jung,
Ally Huang,
K. Jessica Norberg,
Luigi Marchionni,
Ross McMillan,
Vesselin Penchev,
N. V. Rajeshkumar,
Anirban Maitra

x

Published: July 10, 2017
https://doi.org/10.1371/journal.pone.0180181

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