A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease

Hai-Yan Xing; Bin Li; Dan Peng; Chun-Yan Wang; Guan-Ying Wang; Pan Li; Ying-Ying Le; Ji-Ming Wang; George Ye; Jian-Hong Chen

doi:10.1371/journal.pone.0180076

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Open Access

Peer-reviewed

Research Article

A novel monoclonal antibody against the N-terminus of Aβ_1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease

Hai-Yan Xing,

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacy, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China
⨯
Bin Li,

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Pharmacy, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China
⨯
Dan Peng,

Roles Methodology

Affiliation Department of Pharmacy, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China
⨯
Chun-Yan Wang,

Roles Methodology

Affiliation Anogen-Yes Biotech, Mississauga, Ontario, Canada
⨯
Guan-Ying Wang,

Roles Methodology

Affiliation Department of Pharmacy, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China
⨯
Pan Li,

Roles Methodology

Affiliation Department of Pharmacy, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China
⨯
Ying-Ying Le,

Roles Resources

Affiliation Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China
⨯
Ji-Ming Wang,

Roles Resources, Writing – review & editing

Affiliation Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, United States of America
⨯
George Ye,

Roles Conceptualization, Resources

Affiliation Anogen-Yes Biotech, Mississauga, Ontario, Canada
⨯
Jian-Hong Chen

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Supervision

* E-mail: chenjh-110@263.net

Affiliation Department of Pharmacy, Daping Hospital & Research Institute of Surgery, Third Military Medical University, Chongqing, China
⨯

A novel monoclonal antibody against the N-terminus of Aβ_1-42 reduces plaques and improves cognition in a mouse model of Alzheimer’s disease

Hai-Yan Xing,
Bin Li,
Dan Peng,
Chun-Yan Wang,
Guan-Ying Wang,
Pan Li,
Ying-Ying Le,
Ji-Ming Wang,
George Ye,
Jian-Hong Chen

Published: June 29, 2017
https://doi.org/10.1371/journal.pone.0180076

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