Extreme low dose of 5-fluorouracil reverses MDR in cancer by sensitizing cancer associated fibroblasts and down-regulating P-gp

• Yan Ma ,

  * E-mail: mygzhtcm@163.com (YM); yhw_albert@163.com (YHW)

  ¶‡ These authors share first authorship of this work.

  Affiliations Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, China

  http://orcid.org/0000-0003-2225-6958

  ⨯
• Yuhua Wang ,

  * E-mail: mygzhtcm@163.com (YM); yhw_albert@163.com (YHW)

  ¶‡ These authors share first authorship of this work.

  Affiliation Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

  ⨯
• Zhenghong Xu,

  Affiliation Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

  ⨯
• Yongjun Wang,

  Affiliations Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China

  ⨯
• John K. Fallon,

  Affiliation Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

  ⨯
• Feng Liu †

  † Deceased.

  Affiliation Division of Molecular Pharmaceutics, Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

  ⨯