Redifferentiation of aged human articular chondrocytes by combining bone morphogenetic protein-2 and melanoma inhibitory activity protein in 3D-culture

Stephan Payr; Brigitte Tichy; Clemens Atteneder; Marc Michel; Thomas Tiefenboeck; Nikolaus Lang; Sylvia Nuernberger; Stefan Hajdu; Elizabeth Rosado-Balmayor; Stefan Marlovits; Christian Albrecht

doi:10.1371/journal.pone.0179729

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Open Access

Peer-reviewed

Research Article

Redifferentiation of aged human articular chondrocytes by combining bone morphogenetic protein-2 and melanoma inhibitory activity protein in 3D-culture

Stephan Payr ,

* E-mail: stephan.payr@meduniwien.ac.at

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Brigitte Tichy,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Clemens Atteneder,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Marc Michel,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Thomas Tiefenboeck,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Nikolaus Lang,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Sylvia Nuernberger,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Stefan Hajdu,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Elizabeth Rosado-Balmayor,

Affiliation Department of Experimental Trauma Surgery, Klinikum rechts der Isar, Technical University Munich, Germany
⨯
Stefan Marlovits,

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯
Christian Albrecht

Affiliations Department of Trauma Surgery, General Hospital, Medical University of Vienna, Austria, Austrian Cluster for Tissue Regeneration, Vienna, Austria
⨯

Redifferentiation of aged human articular chondrocytes by combining bone morphogenetic protein-2 and melanoma inhibitory activity protein in 3D-culture

Stephan Payr,
Brigitte Tichy,
Clemens Atteneder,
Marc Michel,
Thomas Tiefenboeck,
Nikolaus Lang,
Sylvia Nuernberger,
Stefan Hajdu,
Elizabeth Rosado-Balmayor,
Stefan Marlovits

Published: July 13, 2017
https://doi.org/10.1371/journal.pone.0179729

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Cartilage
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Chondrocytes
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Gene expression
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Cell differentiation
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Mesenchymal stem cells
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Articular cartilage
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Collagens
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Histology
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