Evaluation of molecular diagnostic approaches for the detection of BRAF p.V600E mutations in papillary thyroid cancer: Clinical implications

Artur Kowalik; Aldona Kowalska; Agnieszka Walczyk; Renata Chodurska; Janusz Kopczyński; Magdalena Chrapek; Elżbieta Wypiórkiewicz; Małgorzata Chłopek; Liliana Pięciak; Danuta Gąsior-Perczak; Iwona Pałyga; Krzysztof Gruszczyński; Ewelina Nowak; Stanisław Góźdź

doi:10.1371/journal.pone.0179691

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Open Access

Peer-reviewed

Research Article

Evaluation of molecular diagnostic approaches for the detection of BRAF p.V600E mutations in papillary thyroid cancer: Clinical implications

Artur Kowalik ,

* E-mail: arturko@onkol.kielce.pl

Affiliation Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland

http://orcid.org/0000-0002-3718-999X

⨯
Aldona Kowalska,

Affiliation Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland
⨯
Agnieszka Walczyk,

Affiliation Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland
⨯
Renata Chodurska,

Affiliation Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland
⨯
Janusz Kopczyński,

Affiliation Department of Surgical Pathology, Holycross Cancer Centre, Kielce, Poland
⨯
Magdalena Chrapek,

Affiliation Department of Probability Theory and Statistics Institute of Mathematics Faculty of Mathematics and Natural Science, Jan Kochanowski University, Kielce, Poland
⨯
Elżbieta Wypiórkiewicz,

Affiliation Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland
⨯
Małgorzata Chłopek,

Affiliation Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland
⨯
Liliana Pięciak,

Affiliation Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland
⨯
Danuta Gąsior-Perczak,

Affiliation Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland
⨯
Iwona Pałyga,

Affiliation Endocrinology Clinic, Holycross Cancer Centre, Kielce, Poland
⨯
Krzysztof Gruszczyński,

Affiliation Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland
⨯
Ewelina Nowak,

Affiliation Department of Molecular Diagnostics, Holycross Cancer Centre, Kielce, Poland
⨯
Stanisław Góźdź

Affiliations Oncology Clinic, Holycross Cancer Centre, Kielce, Poland, The Faculty of Health Sciences, Jan Kochanowski University, Kielce, Poland
⨯

Evaluation of molecular diagnostic approaches for the detection of BRAF p.V600E mutations in papillary thyroid cancer: Clinical implications

Artur Kowalik,
Aldona Kowalska,
Agnieszka Walczyk,
Renata Chodurska,
Janusz Kopczyński,
Magdalena Chrapek,
Elżbieta Wypiórkiewicz,
Małgorzata Chłopek,
Liliana Pięciak,
Danuta Gąsior-Perczak

Published: June 21, 2017
https://doi.org/10.1371/journal.pone.0179691

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Mutation detection
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Genotyping
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Thyroid carcinoma
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Amplification-refractory mutation system analysis
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Polymerase chain reaction
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Cancer treatment
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Cancers and neoplasms
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Mutation
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