Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury

David M. Rissin; Barbara López-Longarela; Salvatore Pernagallo; Hugh Ilyine; A. D. Bastiaan Vliegenthart; James W. Dear; Juan J. Díaz-Mochón; David C. Duffy

doi:10.1371/journal.pone.0179669

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Open Access

Peer-reviewed

Research Article

Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury

David M. Rissin ,

Contributed equally to this work with: David M. Rissin, Barbara López-Longarela

Affiliation Quanterix Corporation, Lexington, Massachusetts, United States of America
⨯
Barbara López-Longarela ,

Contributed equally to this work with: David M. Rissin, Barbara López-Longarela

Affiliation DestiNA Genomics Ltd., Edinburgh, United Kingdom; DestiNA Genomica S.L. Parque Tecnológico Ciencias de la Salud (PTS), Avenida de la Innovación 1, Edificio BIC, Armilla, Granada, Spain
⨯
Salvatore Pernagallo,

Affiliation DestiNA Genomics Ltd., Edinburgh, United Kingdom; DestiNA Genomica S.L. Parque Tecnológico Ciencias de la Salud (PTS), Avenida de la Innovación 1, Edificio BIC, Armilla, Granada, Spain
⨯
Hugh Ilyine,

Affiliation DestiNA Genomics Ltd., Edinburgh, United Kingdom; DestiNA Genomica S.L. Parque Tecnológico Ciencias de la Salud (PTS), Avenida de la Innovación 1, Edificio BIC, Armilla, Granada, Spain
⨯
A. D. Bastiaan Vliegenthart,

Affiliation Edinburgh University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Edinburgh, United Kingdom
⨯
James W. Dear,

Affiliation Edinburgh University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, Edinburgh, United Kingdom
⨯
Juan J. Díaz-Mochón ,

* E-mail: dduffy@quanterix.com (DCD.); juan@destinagenomics.com (JJD-M)

Affiliations DestiNA Genomics Ltd., Edinburgh, United Kingdom; DestiNA Genomica S.L. Parque Tecnológico Ciencias de la Salud (PTS), Avenida de la Innovación 1, Edificio BIC, Armilla, Granada, Spain, Pfizer-Universidad de Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENYO), Parque Tecnológico de Ciencias de la Salud (PTS), Avenida de la Ilustración 114, Granada, Spain
⨯
David C. Duffy

* E-mail: dduffy@quanterix.com (DCD.); juan@destinagenomics.com (JJD-M)

Affiliation Quanterix Corporation, Lexington, Massachusetts, United States of America
⨯

Polymerase-free measurement of microRNA-122 with single base specificity using single molecule arrays: Detection of drug-induced liver injury

David M. Rissin,
Barbara López-Longarela,
Salvatore Pernagallo,
Hugh Ilyine,
A. D. Bastiaan Vliegenthart,
James W. Dear,
Juan J. Díaz-Mochón,
David C. Duffy

Published: July 5, 2017
https://doi.org/10.1371/journal.pone.0179669

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Polymerase chain reaction
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