Severity classification of repeated isoflurane anesthesia in C57BL/6JRj mice—Assessing the degree of distress

• Katharina Hohlbaum ,

  * E-mail: katharina.hohlbaum@fu-berlin.de

  Affiliations Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany, Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

  http://orcid.org/0000-0001-6681-9367

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• Bettina Bert,

  Current address: Federal Institute for Risk Assessment (BfR), Berlin, Germany

  Affiliation Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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• Silke Dietze,

  Affiliation Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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• Rupert Palme,

  Affiliation Unit of Physiology, Pathophysiology and Experimental Endocrinology, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria

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• Heidrun Fink,

  Affiliation Institute of Pharmacology and Toxicology, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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• Christa Thöne-Reineke

  Affiliation Institute of Animal Welfare, Animal Behavior and Laboratory Animal Science, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany

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