Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression

Lizheng Wang; Zixuan Wang; Rui Zhu; Jinpeng Bi; Xinyao Feng; Wenmo Liu; Jiaxin Wu; Haihong Zhang; Hui Wu; Wei Kong; Bin Yu; Xianghui Yu

doi:10.1371/journal.pone.0179476

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Open Access

Peer-reviewed

Research Article

Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression

Lizheng Wang,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Zixuan Wang,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Rui Zhu,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Jinpeng Bi,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Xinyao Feng,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Wenmo Liu,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Jiaxin Wu,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Haihong Zhang,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Hui Wu,

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Wei Kong,

Affiliations National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Bin Yu ,

* E-mail: yubin@jlu.edu.cn (BY); xianghui@jlu.edu.cn (XY).

Affiliation National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China
⨯
Xianghui Yu

* E-mail: yubin@jlu.edu.cn (BY); xianghui@jlu.edu.cn (XY).

Affiliations National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China, Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin Province, China

http://orcid.org/0000-0001-7739-1386

⨯

Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression

Lizheng Wang,
Zixuan Wang,
Rui Zhu,
Jinpeng Bi,
Xinyao Feng,
Wenmo Liu,
Jiaxin Wu,
Haihong Zhang,
Hui Wu,
Wei Kong

Published: June 16, 2017
https://doi.org/10.1371/journal.pone.0179476

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