2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway

Zhemin Wang; Zewen Qiu; Chenxue Gao; Yijie Sun; Wei Dong; Yan Zhang; Ruolin Chen; Yuan Qi; Shuangyue Li; Yanjie Guo; Yongjun Piao; Sheng Li; Fengyuan Piao

doi:10.1371/journal.pone.0179388

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Open Access

Peer-reviewed

Research Article

2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway

Zhemin Wang ,

Contributed equally to this work with: Zhemin Wang, Zewen Qiu

Current address: Department of prevention and health care, the Second Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia Autonomous Region, China

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China
⨯
Zewen Qiu ,

Contributed equally to this work with: Zhemin Wang, Zewen Qiu

Affiliation Laboratory Animal center, Dalian Medical University, Dalian, Liaoning, China
⨯
Chenxue Gao,

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China
⨯
Yijie Sun,

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China
⨯
Wei Dong,

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China
⨯
Yan Zhang,

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China
⨯
Ruolin Chen,

Affiliation Department of Sexually Transmitted Disease, Heping Center for Disease Control and Prevention of Tianjin, Tianjin, China
⨯
Yuan Qi,

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China
⨯
Shuangyue Li,

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China
⨯
Yanjie Guo,

Affiliation Department of Biochemistry, Dalian Medical University, Dalian, Liaoning, China
⨯
Yongjun Piao,

Affiliation Department of Dermatology, the First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China
⨯
Sheng Li ,

* E-mail: piaofengyuan353@163.com (FP); lisheng_1996@163.com (SL)

Affiliation Department of Biochemistry, Dalian Medical University, Dalian, Liaoning, China
⨯
Fengyuan Piao

* E-mail: piaofengyuan353@163.com (FP); lisheng_1996@163.com (SL)

Affiliation Department of Occupational and Environmental Health, Dalian Medical University, Dalian, Liaoning, China

http://orcid.org/0000-0001-8582-3097

⨯

2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway

Zhemin Wang,
Zewen Qiu,
Chenxue Gao,
Yijie Sun,
Wei Dong,
Yan Zhang,
Ruolin Chen,
Yuan Qi,
Shuangyue Li,
Yanjie Guo

Published: June 27, 2017
https://doi.org/10.1371/journal.pone.0179388

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