Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication

Wenju Liu; Xu Li; Bo Zhou; Shoucai Fang; Wenzhe Ho; Hui Chen; Hao Liang; Li Ye; Jun Tang

doi:10.1371/journal.pone.0179379

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Peer-reviewed

Research Article

Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication

Wenju Liu ,

Contributed equally to this work with: Wenju Liu, Xu Li, Bo Zhou

Affiliation Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, P. R. China
⨯
Xu Li ,

Contributed equally to this work with: Wenju Liu, Xu Li, Bo Zhou

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Collaborative Innovation Centre for Biomedicine, School of Public Health, Guangxi Medical University, Nanning City, Guangxi, P. R. China
⨯
Bo Zhou ,

Contributed equally to this work with: Wenju Liu, Xu Li, Bo Zhou

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Collaborative Innovation Centre for Biomedicine, School of Public Health, Guangxi Medical University, Nanning City, Guangxi, P. R. China
⨯
Shoucai Fang,

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Collaborative Innovation Centre for Biomedicine, School of Public Health, Guangxi Medical University, Nanning City, Guangxi, P. R. China
⨯
Wenzhe Ho,

Affiliation Department of Pathology and Laboratory Medicine, Temple University School of Medicine, Philadelphia, PA, United States of America
⨯
Hui Chen,

Affiliation Geriatrics Digestion Department of Internal Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi, P. R. China
⨯
Hao Liang,

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Collaborative Innovation Centre for Biomedicine, School of Public Health, Guangxi Medical University, Nanning City, Guangxi, P. R. China
⨯
Li Ye ,

* E-mail: tangj0205@whu.edu.cn (JT); yeli@gxmu.edu.cn (LY)

Affiliation Guangxi Key Laboratory of AIDS Prevention and Treatment & Guangxi Collaborative Innovation Centre for Biomedicine, School of Public Health, Guangxi Medical University, Nanning City, Guangxi, P. R. China
⨯
Jun Tang

* E-mail: tangj0205@whu.edu.cn (JT); yeli@gxmu.edu.cn (LY)

Affiliation Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, P. R. China
⨯

Differential induction of apoptosis and autophagy by pyrrolizidine alkaloid clivorine in human hepatoma Huh-7.5 cells and its toxic implication

Wenju Liu,
Xu Li,
Bo Zhou,
Shoucai Fang,
Wenzhe Ho,
Hui Chen,
Hao Liang,
Li Ye,
Jun Tang

Published: June 26, 2017
https://doi.org/10.1371/journal.pone.0179379

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