ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency

• Philippe Joly ,

  Contributed equally to this work with: Philippe Joly, Hélène Vignaud

  Affiliations University Lyon - University Claude Bernard Lyon 1 - EA 7424 – Inter-university Laboratory of Human Movement Science, Villeurbanne, France, Laboratoire de Biochimie et biologie moléculaire Grand-Est, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France

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• Hélène Vignaud ,

  Contributed equally to this work with: Philippe Joly, Hélène Vignaud

  Affiliation CNRS, University Bordeaux, UMR5095 Institut de Biochimie et Génétique Cellulaires, Bordeaux, France

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• Julie Di Martino,

  Affiliations CNRS, University Bordeaux, UMR5095 Institut de Biochimie et Génétique Cellulaires, Bordeaux, France, INSERM, University Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, Bordeaux, France

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• Mathias Ruiz,

  Affiliation Department of Paediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Lyon, Lyon, France

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• Roman Garin,

  Affiliation Department of Paediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Lyon, Lyon, France

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• Lioara Restier,

  Affiliation Department of Paediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Lyon, Lyon, France

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• Abdelouahed Belmalih,

  Affiliation Department of Paediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Lyon, Lyon, France

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• Christelle Marchal,

  Affiliation CNRS, University Bordeaux, UMR5095 Institut de Biochimie et Génétique Cellulaires, Bordeaux, France

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• Christophe Cullin,

  Affiliation CNRS, University Bordeaux, UMR5095 Institut de Biochimie et Génétique Cellulaires, Bordeaux, France

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• Benoit Arveiler,

  Affiliation University Bordeaux, INSERM U1211, Laboratoire Maladies Rares, Génétique et Métabolisme (MRGM), Bordeaux, France

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• Patricia Fergelot,

  Affiliation University Bordeaux, INSERM U1211, Laboratoire Maladies Rares, Génétique et Métabolisme (MRGM), Bordeaux, France

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• Aaron D. Gitler,

  Affiliation Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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• Alain Lachaux,

  Affiliation Department of Paediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Lyon, Lyon, France

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• Julien Couthouis,

  Affiliation Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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• Marion Bouchecareilh

  * E-mail: marionb@ibgc.cnrs.fr

  Affiliations CNRS, University Bordeaux, UMR5095 Institut de Biochimie et Génétique Cellulaires, Bordeaux, France, INSERM, University Bordeaux, UMR1053 Bordeaux Research In Translational Oncology, BaRITOn, Bordeaux, France

  http://orcid.org/0000-0001-9233-4152

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