On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon-free therapy for chronic hepatitis C

• Po-sung Chu ,

  Roles Conceptualization, Investigation, Writing – original draft

  * E-mail: pschu0928@iCloud.com (PSC); takagast@z2.keio.jp (TK)

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

  http://orcid.org/0000-0002-8687-2760

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• Nobuhiro Nakamoto,

  Roles Conceptualization

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Nobuhito Taniki,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Keisuke Ojiro,

  Roles Conceptualization

  Affiliations Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan, Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Takeru Amiya,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Yuko Makita,

  Roles Investigation

  Affiliations Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan, Kitasato University Kitasato Institute Hospital, 5-9-1 Shiragane-dai, Minato-ku, Tokyo, Japan

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• Hiroko Murata,

  Roles Investigation

  Affiliations Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan, Eiju Hospital, 2-23-16 Higashi-ueno, Ueno-ku, Tokyo, Japan

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• Akihiro Yamaguchi,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Shunsuke Shiba,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Rei Miyake,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Tadashi Katayama,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Aya Ugamura,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Akihiko Ikura,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Karin Takeda,

  Roles Investigation

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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• Hirotoshi Ebinuma,

  Roles Conceptualization

  Affiliations Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan, International University of Health and Welfare Mita Hospital, 1-4-3 Mita, Minato-ku, Tokyo, Japan

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• Hidetsugu Saito,

  Roles Conceptualization

  Affiliations Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan, Division of Pharmacotherapeutics, Keio University School of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo, Japan

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•  [ ... ],
• Takanori Kanai

  Roles Conceptualization, Writing – original draft

  * E-mail: pschu0928@iCloud.com (PSC); takagast@z2.keio.jp (TK)

  Affiliation Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, Japan

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